1H spectroscopy: validation in vivo

نویسندگان

  • LIDIA S. SZCZEPANIAK
  • EVELYN E. BABCOCK
  • FRITZ SCHICK
  • ROBERT L. DOBBINS
  • DANIEL T. STEIN
چکیده

LIDIA S. SZCZEPANIAK,1,2 EVELYN E. BABCOCK,3 FRITZ SCHICK,4 ROBERT L. DOBBINS,1,2 ABHIMANYU GARG,2 DENNIS K. BURNS,5 J. DENIS MCGARRY,1,2,6 AND DANIEL T. STEIN1,2 1Center for Diabetes Research, Departments of 2Internal Medicine, 3Radiology, 5Pathology, and 6Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235; and 4Department of Radiology, University of Tübingen, 72706 Tübingen, Germany

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Investigation of Behavior of Forced Degradation of Lidocaine HCl by NMR Spectroscopy and GC-FID Methods: Validation of GC-FID Method for Determination of Related Substance in Pharmaceutical Formulations

  The forced degradation study of lidocaine HCl was carried out according to the ICH guideline Q1A (R2). The degradation conditions were assessed to be hydrolysis, oxidation, photolysis and dry heat during 24 h, 48 h and 72 h and then the samples were investigated by GC-FID method and nuclear magnetic resonance (NMR) spectroscopy. According to these results, the degradation products were not o...

متن کامل

Ex vivo HR-MAS MRS of human meningiomas: A comparison with in vivo 1H MR spectra VITALIANO TUGNOLI1, LUISA SCHENETTI2, ADELE MUCCI2, FRANCESCA PARENTI2, RITA CAGNOLI2, VALERIA RIGHI1,2, ANDREA TRINCHERO1, LUCA NOCETTI3, CRISTIAN TORACI3, LUCIANO MAVILLA4, GIANPAOLO

We report on the magnetic resonance spectroscopy (MRS) characterisation of different human meningiomas. Three histological subtypes of meningiomas (meningothelial, fibrous and oncocytic) were analysed both through in vivo and ex vivo MRS experiments. The ex vivo high-resolution magic angle spinning (HR-MAS) investigations, permitting an accurate description of the metabolic profile, are very he...

متن کامل

Investigation of Behavior of Forced Degradation of Lidocaine HCl by NMR Spectroscopy and GC-FID Methods: Validation of GC-FID Method for Determination of Related Substance in Pharmaceutical Formulations

  The forced degradation study of lidocaine HCl was carried out according to the ICH guideline Q1A (R2). The degradation conditions were assessed to be hydrolysis, oxidation, photolysis and dry heat during 24 h, 48 h and 72 h and then the samples were investigated by GC-FID method and nuclear magnetic resonance (NMR) spectroscopy. According to these results, the degradation products were not o...

متن کامل

A comparison between in vivo and ex vivo HR-MAS 1H MR spectra of a pediatric posterior fossa lesion.

The present case report was aimed at identifying the molecular profile characteristic of a primitive neuro-ectodermal tumor (PNET) in a 3-year-old child affected by a lesion localized in the cerebellar region. The histological diagnosis was medulloblastoma. In vivo single voxel 1H magnetic resonance spectroscopy (MRS) shows high specificity in detecting the main metabolic alterations in the pri...

متن کامل

Metabolomics-Based Study of Logarithmic and Stationary Phases of Promastigotes in Leishmania major by 1H NMR Spectroscopy

Background: Cutaneous leishmaniasis is one of the most important parasitic diseases in humans. In this disease, one of the responsible organisms is Leishmania major, which is transmitted by sandfly vector. There are specific differences in biochemical profiles and metabolite pathways in logarithmic and stationary phases of Leishmania parasites. In the present study, 1H NMR spectroscopy was used...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 1999